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Urofollitropin- is a purified form of follicle-stimulating hormone

Urofollitropin is a purified form of follicle-stimulating hormone that is manufactured by extraction from human urine and then purified to remove various proteins and other substances. More

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Description

Urofollitropin is a purified form of follicle-stimulating hormone that is manufactured by extraction from human urine and then purified to remove various proteins and other substances.

Generic Name

Urofollitropin- is a purified form of follicle-stimulating hormone

Chemical names

Urofollitropin; CHEMBL3249216; CHEMBL3276116

Brand names

Bravelle, Eema-FSH, Endogen, Eogentin, Eogentin-HP, Evahope-F HP, Eventin 150(HMG), Eventin 75(HMG), Fergonad-F, Foliculin, Foligem, Foligest, Foligraf, Folliova, Follitec, Follokon, Fostine, Gonal-F, Gonal-F 300IU PEN, Go

IUPAC name

Pharmacokinetics

Actions

Urofollitropin or FSH stimulates ovarian follicular growth in women who do not have primary ovarian failure. Follicle stimulating hormone is the active component of urofollitropin is the primary hormone responsible for the follicular development and recruitment.

Dosage/Dosage form

Initially, 150 IU daily for the first 5 days, increase up to 450 IU daily SC/IM for Female infertility.

Therapeutic uses

For treatment of female infertility

Adverse effects/Side effects

Ovarian cysts rupture, intraperitoneal haemorrhage, breast tenderness, mild diarrhea, nausea, or vomiting, constipation and hot flashes. Nausea, vomiting, joint pain, ovarian hyperstimulation syndrome, adnexal torsion, mild to moderate ovarian enlargement, abdominal pain, ovarian cysts, local reaction at inj site, headaches, haemoperitoneum, benign and malignant ovarian neoplasms, ascites, pleural effusion, hypovolaemia, thromboembolic disorders. Weight gain, acne and gynaecomastia in men.

Interaction

Increased risk of ovarian hyperstimulation syndrome with drugs with luteinising hormone activity.

Contraindications

Pregnancy, ovarian cysts or enlargement not due to polycystic ovary syndrome, primary ovarian failure, organic intracranial lesion e.g. pituitary tumour, uncontrolled thyroid and adrenal dysfunction, presence of any cause of infertility other than an ovulation, abnormal bleeding of undetermined origin.

Storage

Store it at room temperature in an air tight container and keep away from children.               

Information

Molecular weight

980.162 Da

Molecular formula

C42H65N11O12S2

CAS number

26995-91-5

Precautions

May result in multiple pregnancies. Abnormal genital bleeding, hormone sensitive malignancies, ovarian cysts not caused by polycystic ovary syndrome. Exclude and treat other causes of infertility e.g. pituitary or hypothalamic lesions, adrenal or thyroid disorders and hyperprolactinaemia.