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Ursodiol-used to dissolve certain types of gallstones

Ursodiol is used to dissolve certain types of gallstones, to prevent gallstones from forming in obese patients who are losing weight rapidly, and to treat a certain type of liver disease More

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Description

Ursodiol is used to dissolve certain types of gallstones, to prevent gallstones from forming in obese patients who are losing weight rapidly, and to treat a certain type of liver disease

Generic Name

Ursodiol-used to dissolve certain types of gallstones

Chemical names

Ursodiol; ursodeoxycholic acid; Ursolvan; Actigall

Brand names

Actibile, Actibile Child, Culiv-VD, Estuchol, Golbi, GSD, Intraliv-UD, Livdol, Livokind, Solubid, Udbest, Udebile, Udfast, Udicol, Udihep, Udihep Forte, Udiliv, Udimarin Forte, Udkare, Udlife, Udmin, Udoxyl, Udxic, Urchil,

IUPAC name

(4R)-4-[(1S,2S,5R,7S,9S,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,?.0¹¹,¹?]heptadecan-14-yl]pentanoic acid

Pharmacokinetics

  • Rapidly and completely absorbed from the GI tract.
  • 96-98% protein medium.
  • Excreted through Faeces. 

Actions

Ursodiol is the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Primary bile acids are produced by the liver and stored in the gall bladder. Primary and secondary bile acids help the body digest fats. It helps to regulate cholesterol by reducing the rate at which the intestine absorbs cholesterol molecules while breaking up micelles containing cholesterol. Because of this property, ursodeoxycholic acid is used to treat gall stones non-surgically.

Dosage/Dosage form

The recommended dose is 8-10 mg/kg/day split into 2/3 doses.

Therapeutic uses

Adverse effects/Side effects

Diarrhoea, pruritus, nausea, vomiting, gallstone calcification.

Interaction

  • Cholestyramine, charcoal and antacids may reduce effectiveness.
  • Aluminum-based antacids may reduce absorption.
  • clofibrate and oestrogens may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile.
  • Possible increase in ciclosporin serum concentration.
  • Decreased effectiveness of dapsone.
  • Possible decrease in serum ciprofloxacin and nitrendipine.

Contraindications

Calcified and pigment gallstones, radio opaque gallstones. Nonfunctioning gall bladders; chronic liver and peptic ulcer disease. Inflammatory disease of colon and small intestine.

Pregnancy.

Storage

Store it at 20-25 degree centigrade.

Information

Molecular weight

392.572

Molecular formula

C24H40O4

CAS number

128-13-2

Precautions

Avoid excess dose.