Valdecoxib

Valdecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor.

Valdecoxib

Valdecoxib; Bextra; 4-(5-methyl-3-phenylisoxazol-4-yl) benzenesulfonamide; 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide

Artival, Bioval, Creval, Leap, Mobyle-V-20, Nizox, Osra, Oval-20, Parovi, Powercoxib, Revaldo, Revaldo Gel, Revaldo QR, Ronaldo, Tpveld, Vabra, Vabra-P, Vabra-SPD, Vabra-TZ, Vacox, VAH, Vah Gel, Vahflam, VAL-BCD, Valac, Valcib, Valcox Plus, Valdegesic, Valdegesic-P, Valdepain, Valdez, Valdiff, Valdiflam, Valdine, Valdixx MD, Valdone, Valdy, Valdy-MD, Valed, Valeron, Valeron Plus, Valigud, Valiy, Valk, Valk Plus, Valoxib, Valsafe, Valsafe-MR, Valto, Valus.

4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide

NA

Valdecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Valdecoxib is used for its anti-inflammatory, analgesic, and antipyretic activities in the management of osteoarthritis (OA) and for the treatment of dysmenorrhea or acute pain. 

10 mg once daily oral.

For the treatment of osteoarthritis and dysmenorrhoea

Toxic epidermal necrolysis, exfoliative dermatitis. Hypertension, back pain, myalgia, peripheral oedema, influenza-like symptoms, dizziness, headache, abdominal fullness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, myalgia, sinusitis.

• Concomitant admin of aspirin may result in an increased risk of GI ulceration and complications.
• It decreases the antihypertensive effect of antihypertensive e.g. ACE inhibitors.
•  It increases plasma concentration of dextromethorphan.
•  It significantly decreases lithium serum clearance and renal clearance.

Hypersensitivity to sulfonamides, NSAIDs and other COX 2 inhibitors; asthma, urticaria; severe hepatic impairment; pregnancy (third trimester); lactation. Active GI bleed or ulceration, severe CHF, inflammatory bowel disease.

Store below 30°C.

Molecular weight

314.359

Molecular formula

C16H14N2O3S

CAS number

181695-72-7

Precautions

• Mild to moderate hepatic impairment; history of ulcer disease or GI bleeding; dehydration, hypertension, history of heart failure, left ventricular dysfunction, pre-existing oedema.
• Monitor Hb or haematocrit values for signs and symptoms of anaemia.