Valethamate

Valethamate is an anticholinergic drug used as smooth muscle relaxant.

Valethamate

Valethamate; Epidosan; NCGC00185757-01; Letamate

Epidosin, Osdil, Valosin

N,N-Diethyl-N-methyl-2-[(3-methyl-2-phenylpentanoyl)oxy]ethanaminium

NA

NA

• 8-16 mg/day as IV/IM
• Per tab contains 10mg of valethamate and 325 mg of paracetamol as PO.

It is an antispasmodic agent, Used for the treatment of Dysmenorrhoea, Postoperative pain, Visceral spasms, Gastrointestinal tract spasm, Tenesmus, Urinary tract and bile stone colic. 

Dry mouth, blurring of vision, difficulty in swallowing and talking, constipation, urinary retention, mydriasis, arrhythmias.

• Increased antimuscarinic side effects with drugs with antimuscarinic properties e.g. amantadine, antihistamines, phenothiazide antipsychotics, TCAs.
• Delayed gastric emptying reduces absorption of other drugs.
• Antagonise GI effects of domperidone, metoclopramide. 

• Narrow angle glaucoma, benign prostatic hyperplasia, paralytic ileus, pyloric stenosis, ulcerative colitis, megacolon, and tachyarrhythmia.
• Severe hepatic and renal impairment.

Store below 25°C. 

Molecular weight

306.47 g/mol

Molecular formula

C19H32NO2+

CAS number

16376-74-2

Precautions

May impair ability to drive or operate machinery at high doses.