Valproic acid or valproate

It is a chemical compound used as a mood-stabilizing drug and anticonvulsant, primarily in the treatment of epilepsy, bipolar disorder, and less commonly major depression.

Valproic acid or valproate

: 2-Propylpentanoic acid; 99-66-1; Dipropylacetic acid; Depakene

Divuna-ER, Encorate, Encorate Chrono, Epilex, Epival, Epsoval, Epsoval-XR, Manoval, Soric, Torvate, Torvate Chrono, TP Valpro-300, Val, Valance SOLN, Valate, Valkid, Valparin, Valpofin-CR, Valporate Chrono, Valporil, Valporil CR, Valprid, Valprol SYR, Valrate-CR, Valric, Valtec, Valtec-CR, Valtril, Zorat

2-propylpentanoic acid

Oral absorption

Valproic Acid dissociates to the valproate ion in the gastrointestinal tract and then binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Valproic Acid may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. It is also a histone deacetylase inhibitor. It also has been shown to be an inhibitor of histone deacetylase 1 enzyme (HDAC1). HDAC1 is needed for HIV to remain in infected cells. 

The recommended dose is 15 mg/kg/day per oral.

For treatment and management of seizure disorders, mania, and prophylactic treatment of migraine headache.

Nausea, vomiting, abdominal pain, headache, lung inflammation, hair loss, infections, night blindness and heart burn.

• Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases, may increase the clearance of Valproate. For example, carbamazepine, Phenytoin and phenobarbital (or primidone).Thus, patients on monotherapy will generally have longer half-lives and higher concentrations than patients receiving polytherapy with antiepilepsy drugs.

Contraindicated in patients with known urea cycle disorder and hypersensitivity.

Store it at room temperature.

Molecular weight

144.2114

Molecular formula

C8H16O2

CAS number

99-66-1

Precautions

• Valproate is contraindicated in overweight patients because it might cause weight gain.
• Avoid excess dose.