Vasopressin

Vasopressin, also known as antidiuretic hormone, is a neurohypophysial hormone found in most mammals which is also used as a medication. In most species it contains arginine and is thus also called arginine vasopressin or argipressin.

Vasopressin

Arginine vasopressin; Argipresina; Argipressinum; 8-Arginine-vasopressin

Cpressin, Cpressin-P, Petresin, Vascel, Vasmed, Vasopin, Vpress

1-{[(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-L-p rolyl-L-arginylglycin

1% protein binding.

This is an antidiuretic hormone used for the prevention and treatment of diabetes insipidus, postoperative abdominal distention, and in abdominal roentgenography to dispel interfering gas shadows. This can cause contraction of smooth muscle of the GI (gastrointestinal) tract and of all over the parts of the vascular bed, especially the small arterioles, capillaries, and venules. It is also prescribed to treat extreme cases of bed wetting in children, to control bleeding in some forms of von Willebrand disease and this plays a role in memory formation although the mechanism is unknown.

5-20 units, IV or parenteral.

For the treatment of diabetes insipidus, enuresis, polydipsia, polyuria and oesophageal varices with bleeding.

Pallor, anaphylaxis; cardiac arrest or shock. Vomiting, tremour, belching, nausea, headache, abdominal cramps, fluid retention, vertigo, hypersensitivity reaction, hyponatraemia, urticaria, sweating, bradycardia, gangrene, arrhythmias, desire to defecate, angina, MI and bronchoconstriction.

• Clofibrate, carbamazepine, fludrocortisones, chlorpropamide, urea, and tricyclic antidepressants may potentiate the antidiuretic action of vasopressin.
• Demeclocycline, noradrenaline, lithium, heparin and alcohol may decrease antidiuretic action of vasopressin.
• The pressor effect of vasopressin sensitivity may increase by ganglionic blockers.
• Increased risk of QT prolongation with dolasetron.

• Hypersensitivity.
• Vascular disease especially coronary artery disease; chronic nephritis (until reasonable blood-nitrogen concentration attained).

Store between 15-25°C (59-77°F). 

Molecular weight

1084.232 Da

Molecular formula

C46H65N15O12S2

CAS number

11000-17-2

Precautions

• Adjust fluid intake to avoid fluid overload. Lactation, pregnancy (especially 3rd trimester as it may have oxytocic effect).
• Asthma, Migraine, heart failure; epilepsy or other conditions; might be exacerbated by renal impairment; fluid retention; hypertension or other conditions that may worse with BP increase.