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Vitamin D

Vitamin D refers to a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, phosphate, and zinc and multiple other biological effects. More

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Description

Vitamin D refers to a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, phosphate, and zinc and multiple other biological effects.

Generic Name

Vitamin D

Chemical names

Vitamin D3; Cholecalciferol; Calciol; Colecalciferol

Brand names

Absolut Syr, Ao-7, Becadex, Becadex DPS, Calcinet-Lfa, Calvon, Carbifol Syr, Chewtab Multivit, Delvit, Dropovit, Eldervit Dps, Eldervit Syr, Glucose-D, Hexavit, Hovite Syr, Kelcer Plus, Lacrisan, M.V.I., Maximin Inf, Nestosule-MV, Nestosule-MV Syr, Nidcal-AF, Nurrish, Nurture, Oliade Bath Oil, Osteo, Osteo-G, Sharkovit, Styptocid, Vi-Magna Dps, Vi-Syneral Z, Vi-Syneral Zinc, Vimin

IUPAC name

(1S,3Z)-3-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol

Pharmacokinetics

Readily absorbed.

Actions

It (Cholecalciferol) is a steroid hormone. Deficiency in adults leads to the disease osteomalacia, rickets seen in children and results in bony deformaties including bowed long bones. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D will play an important role in the regulation of parathyroid hormone (PTH) and in maintaining calcium balance. It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma.

Dosage/Dosage form

NA

Therapeutic uses

Familial hypophosphatemia, vitamin D insufficiency or deficiency, refractory rickets (vitamin D resistant rickets), and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis treatment. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis.

Adverse effects/Side effects

NA

Interaction

This is interacted with calcipotriene, aluminium salts, thiazide diuretics, tinzaparin, digoxin, cimetidine, enoxaparin, low-molecular weight heparin, verapamil and diltiazem.

Contraindications

Pregnancy and lactation

Storage

Protect away from light and moisture.

Information

Molecular weight

384.6377

Molecular formula

C27H44O

CAS number

67-97-0

Precautions

Vitamin D is contraindicated in patients with renal disorders, hypercalcemia, sarcoidosis, hyperparathyroidism, histoplasmosis, atherosclerosis and lymphoma.