Xipamide- medicine which increases the amount of urine

Xipamide is a sulfonamide diuretic drug marketed by Eli Lilly under the trade names Aquaphor and Aquaphoril. It is used for the treatment of oedema and hypertension.

Xipamide- medicine which increases the amount of urine

Xipamid, 4-chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide; Diurexan

Xipamid, Eli Lilly

4-Chloro-N-(2,6-dimethylphenyl)-2-hydroxy-5-sulfamoylbenzamide

Rapid and well absorbed from GI tract, 99% protein binding and excreted via urine.

• 20 mg/day in the morning for hypertension
• 40 mg/day in the morning, dose will be reduces to 20 mg as needed for edema. Maximum dose is 80 mg.

Hypertension, oedema.

GI disturbances; hypokalaemia; hyperuricaemia; nocturia, dizziness; impaired glucose metabolism.

• Antihypertensives enhance BP-lowering effects of xipamide. Increased risk of hypokalaemia with amphotericin B, carbenoxolone.
• Propensity to cause hypokalaemia can increase risk of digitalis toxicity.

Hypersensitivity to sulphonamide. Precomatose states associated with cirrhosis; Untreated Addison's disease, severe electrolyte deficiency; severe renal failure; lactation.

Store it at room temperature and in air tight container.

Molecular weight

354.809 Da

Molecular formula

C15H15ClN2O4S

CAS number

14293-44-8

Precautions

Pregnancy; elderly. renal or hepatic impairment; Prostatic hypertrophy; hypovolaemia; hyperuricaemia;DM; severe coronary or cerebral arteriosclerosis.