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Zolpidem-is a sedative- hypnotic.

Zolpidem is a sedative primarily used for the treatment of insomnia. It works quickly, usually within 15 minutes, and has a short half-life of two to three hours. More

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Description

Zolpidem is a sedative primarily used for the treatment of insomnia. It works quickly, usually within 15 minutes, and has a short half-life of two to three hours.

Generic Name

Zolpidem-is a sedative- hypnotic.

Chemical names

Zolpidem; Ambien; Zolpidemum; Lorex

Brand names

Ambulax-Z, Dactive, Dem, Inzofresh, Isodem, Nidra, Nitrest, Olpitric, Pedo, Sobrium, Sove, Sove-It, Soza, Stilnoct, Syzol, Zanlop, Zleep, Zoal, Zolcent, Zoldem, Zolep, Zolfresh, Zolpel, Zolpicalm, Zolpid, Zolpirest, Zolpis

IUPAC name

N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide

Pharmacokinetics

Actions

Zolpidem is a sedative or hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, zolpidem in vitro binds the (alpha1) receptor preferentially.

Dosage/Dosage form

The recommended dose is 12.5 mg once immediately before bed time.

Therapeutic uses

For the short-term treatment of insomnia.

Adverse effects/Side effects

Hepatitis, anaphylactic reactions, drowsiness, amnesia, dizziness, diarrhoea, nausea, vomiting, abnormal thinking and behaviour, drugged feelings, back pain, ataxia, hiccups, confusion, euphoria, insomnia, vertigo, diplopia, abnormal vision.

Interaction

  • Increased risk of prolonged sedation and respiratory depression with ritonavir.
  • Increased sedation and incoordination with TCA.
  • Small increase in zolpidem concentration with ketoconazole. Reduced effect of hypnotic effects with rifampicin.

Increased sedation with haloperidol and alcohol.

Contraindications

Severe hepatic insufficiency

Storage

Store between 20-25°C (68-77°F).

Information

Molecular weight

307.3895

Molecular formula

C19H21N3O

CAS number

82626-48-0

Precautions

Obstructive sleep apnoea, myasthenia gravis, compromised respiratory function, hepatic impairment. Caution in patients exhibiting symptoms of depression. Patients should be warned from doing any work involving mental alertness or motor coordination after ingestion of the drug. Pregnancy and lactation. Re-evaulate if insomnia fail to remit after 7-10 days. Max duration of treatment: 4 weeks including tapering.