Zotepine-an atypical antipsychotic drug

Zotepine is an atypical antipsychotic drug indicated for acute and chronic schizophrenia. It has been used in Germany since 1990 and Japan since 1982.

Zotepine-an atypical antipsychotic drug

Zotepine; Nipolept; Lodopin; Zoleptil

[2-({6-chloro-2-thiatricyclo[9.4.0.0³,?]pentadeca-1(15),3,5,7,9,11,13-heptaen-9-yl}oxy)ethyl]dimethylamine

Zotepine is an antagonist at central Dopamine (D1 and D2) receptors. This drug binds with serotonin, adrenergic receptors, and H1 (histamine) receptors. Zotepine selectively inhibits noradrenaline reuptake.

25 mg of Zotepine thrice daily oral. 

For the treatment of acute and chronic schizophrenia.

• Zotepine may interact with CNS depressants, sedatives, hypnotics, anti-hypertensive drugs, anesthetic drugs and anti-muscarinic drugs.
• Do not consume alcohol while taking Zotepine. Alcohol may cause additive effects.

Lactation.

Molecular weight

331.86

Molecular formula

C18H18ClNOS

CAS number

26615-21-4

Precautions

• Monitor ECG, LFTs and electrolyte profile regularly while taking Zotepine. 
• Zotepine is contraindicated in patients with pre-existing QT prolongation, renal stones, acute gouty attacks, paralytic ileus, CNS depression, CAD with or without angina pectoris, pheochromocytoma, prostate hyperplasia, neuroblastoma, Parkinson’s disease, closed-angle glaucoma, behavioural disorders and convulsion. 
• Do not withdraw Zotepine abruptly to avoid withdrawal symptoms.